We’ve defined a clear path to drugs and interventions.

Research studies currently funded — either in whole or part — by LuMind IDSC, target each of our four strategic scientific categories that span four independent but interlinked life-stages, beginning during prenatal development and extending into old age.

Prevent Alzheimer's


Improve Cognition and Independence Infographic


Gene Therapy Infographic

Gene Therapy

Access to Treatments Infographic

Access to

Targeting important developmental periods in the lives of people with Down syndrome may be a more successful strategy for improving overall quality of life. As an individual grows and matures, there are unique processes that underlie cognitive development and function.

Preventing Alzheimer’s Disease
  • LuMind IDSC intends to support industry-led clinical trials of therapeutic approaches by: supporting the development of adaptive assessment scales, which account for the variation in symptoms; establishing DS-CTN, a clinical trial network; and engaging Pharma to support trials.


  • To gain a better understanding of cognition in Down syndrome, LuMind IDSC will support research on the validation of specific cognitive targets, the unique sleep patterns and techniques to improve sleep among those with Down syndrome; and finding treatments for other issues related to speech, hearing, and regression.


Gene Therapy
  • Gene therapy is an exciting avenue for possible treatment. In females, the second X chromosome is silenced. Research into some specific genes, Dyrk1A and USP16, may show that the same could be achieved with the third 21st chromosome. Research will be funded on restoring the right level of specific gene(s).


Access to Treatments
  • Our focus is to accelerate research and clinical trials, improve medical care, and support reimbursement.

Research Spotlights

Preventing Alzheimer’s
Landmark clinical trial
of a therapeutic agent
for adults with DS
AC Immune/UCSD
DS Clinical Trials Network
Blazing a trail to
conduct large, multi-site
trials for Down syndrome.
Visit DS-CTN.org
LIFE-DSR: Longitudinal Investigation
A natural history study
to understand progression
of aging and AD in DS
Learn More
Accumulation of Misfolded Tau
Cerveau Technologies
partners to add imaging
sub-study to LIFE-DSR
Read Press Release
Developing gene therapies
Attempt to silence some
extra genes on chromosome
21 through gene therapy
UConn Health
Advance understanding
Stem cell research using
skin cells of individuals
with and without DS
MIT - Picower Institute
Research and Medical Care FB Group
For caregivers to stay
up-to-date on DS research
and medical care advances
Join Today
Improving cognition
Learning Through Objects
in Infants and Toddlers
Observational study
Vanderbilt University